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　エイシンながいけ

肝臓疾患とフェレットLiver Disorder and Ferret

Is the liver disorder developed by zinc shortage and excess protein?

POINT: Implication that ferret liver disorder seems to be caused by the combination of ferret surroundings which tend to lack zinc and excess protein in ferret food.

Compared with dog or cat, ferret tends to have liver disorders a lot like it is natural for ferret to have bad level for its liver. But nobody knows the answer to the question “Why?”

The level is expressed in the abbreviations, GPT or GOT, which are for deviation enzyme. These expressions sometimes differ depending on the testing machine. For human beings, the normal level is lower than 35, but for ferret, it is often considered as the normal level even if it is 400.(unit=IU/dl)

This level is to measure how much the enzyme in liver cells appears in blood and also to recognize how much cells are destroyed. This enzyme exists in other organs, but it is mainly in liver. Therefore the worth level of liver shows that the liver is disordered and the level number 400 obviously shows that the live is in bad condition.

However, ferret doesn’t really seem to care about the liver condition, and it moves lively as normal. So we misunderstand that the liver condition doesn’t really matter for ferret. But it is an obvious truth that its cells are destroyed.

This liver problem is my first challenge when I started to my research in 1998. I found out how to deal with it and the point of a solution, and had good results for those. If the condition or timing is appropriate, the level will be the normal level, and there won’t be much side effect on ferret liver even some amount of medicine is given to ferret.

At first, all I knew was that there was a matter which injures cells, but I could not figure out what it was. I assume that even veterinarians or ferret researchers could not figure it out either.


Suppose, for instance, there is an enemy. And he attacks you with a bow and arrows, and it hits your friend. And your friend is bleeding.

Take your friend as cells, and his blood as the enzyme from ferret liver.

What I was doing was striking off the arrow shot by the enemy. But I had no idea what was the enemy.

In my perspective, the matter( the enemy ) could be a xenobiotic substance or a medical substance which detoxifies in liver. But it was difficult for me to understand that ferret could resupply that amount of those substances in peacetime. It could be understandable if the liver function disorder occurred by the specific food. However, it occurred no matter which makers food ferret eats. That’s why I thought there should be other reasons.

In 2008, my research was concentrated on amino-acid analysis and protein. I was checking how protein was detoxified in liver. Protein ( amino-acid ) is detoxified in liver and excreted by kidney. I wanted to know whether this would be related to the number of liver and kidney disease.

Cat tends to have more kidney disease than ferret. But ferret food has more protein than cat food. I could not figure out this.

“Higher rate of protein in food should strain on ferret.” “Zinc requirement of ferret should be high.” I had had these views for a long time and found the description which explains the reason what increases liver disease by connecting these two views.

“There are many evidences which show that zinc insufficiency is found in many patients with liver disease. (snip) Zinc insufficiency banefully behaves in many aspects in ammonia metabolism.” (adapted from SimpsonWaltham Book of Clinical Nutrition of The Dog & Cat)

This ammonia metabolism occurs in liver. And the liver disease includes rise of GPT or GOT.

It should be understandable that the amount is large for liver to dispose because of the large amount of protein. And when zinc insufficiency occurs at the same time, liver disease is developed.

Ferret can’t store protein that much, and this causes high-protein. But work rate of liver increased because it can’t recycle protein very well.

Now, is zinc insufficient? I am convinced that zinc insufficiency is related to ferret’s condition by my research. In my research, adrenal disease and insulinoma are found in ferrets a lot, and I have discovered that a lot of zinc is ordinarily required to be consumed in these organs. Indeed, ferret physical condition is improved by controlling the amount of zinc to give, and this shows that zinc tend to be short in ferret. Large amount of nutrient is required to produce sex hormone or insulin, and zinc is also required. The case that any changes can be seen in ferret growth as given nutrition which is important minerals for growth hormones can be seen as deficiency of nutrients including zinc or other nutrients.

Zinc tends to be lost in heated or processed food So it is not clear whether even dried food can provide the required amount of zinc to ferret or not. Ferret may naturally require more amount of zinc, because they tend to have overproduction of sex hormones before adrenal disease is clearly seen.

Moreover prednisone, which is a steroid drug and used for insulinoma treatment, accelerates the zinc consumption. We are not really sure if it’s whether the drug is used or zinc insufficiency is related, but GPT or GOT tends to be risen

This gives me an idea that there should be some influences if zinc is enough supplied.

Thus, when zinc insufficiency and protein intake occur in ferret body at the same time, they can be “enemies” in the analogy which I mentioned above.

Certainly I have some examination items to supply supplements. And zinc support is always required in my items. Also I recommend to take zinc for ferrets with adrenal disease and insulinoma. Because of my 10-year experience, I understand how ferret will have a reaction in accordance with how much the supplement is given to ferret. So I know the amount of the supplement to give. Then the level of GPT or GOT is proper, and I hardly hear about problems of ferret liver from my customers who give the proper amount of supplements. So I assume that nutritional support should be related.
　

The proper amount of supplements is one large scoop of muddler per 1kg for healthy ferret. After three years old, the amount can be added depending on the situation of removing active oxygen or its heath condition.

By finding the statement “Zinc insufficiency banefully behaves in many aspects in ammonia metabolism,” I reconfirmed that ferret tends to have zinc insufficiency. And I hope that this information can be a step to reduce ferret liver disease and for ferret healthy life.

In the book “Vitamin Bible,” it is said “Most of zinc is lost in food process. So it is really doubtful t whether necessary amount of zinc for ferret is included in dried food. Zinc has a wide margin of safety. I am convinced that my research can leads ferret happiness by using the knowledge of the zinc use to reduce ferret liver disease.

WARNING: DO NOT give too much zinc to ferret. There is a possibility of zinc excess if too much zinc is given. Minerals or vitamins work in group setting, so we don’t recommend to give only one mineral or vitamin to ferret.

CITATION
Josephine M. Wills and Kenneth W., SimpsonWaltham Book of Clinical Nutrition of The Dog & Cat, Waltham Centre for Pet Nutrition, 1994

Responsibility for wording of this article: Kiyoshi Nagaike, Ferret nutrition expert and Ferret supplement distributor, authored five books.
This article is from his sentence from the magazine “PETTO NO MIKATA.”

The reporter takes full responsibility for the wording and content of this article

　毎年言うことかも知れませんが、私は今の時期が好きです。

ひとつ前のブログで記載した春の生き物のことも同様ですが、植物も春を目指して目覚しく息づいています。静岡市は桜の開花が終わり、全国一位でした。昨年も一位だったようでとても暖かい街と言うことでしょう。静岡市の桜の標準木はフェレットショウ会場の近所です。

　生き物の話を前回したので今回は春の植物。

　梅が咲いたと思えば桃になるのですが、我が家は入り口に植樹しているシンボルツリーは花桃で、まだ咲いていません。今年は非常に遅いです。今生きている桃の木は４本あるのですが、咲いたのは菊花という品種のみ。残りはまだまだです。

　先日から行者ニンニクが芽吹いてきました。食べられるサイズになっていますが、母親に３本届けて、残りは株分けをします。ニラのような姿をしてニンニクの香りがします。非常においしく、８年ほど前にそのてんぷらに出会って、栽培することにしまして株分けをしています。寒い地方の山菜と思うので根付くと思っていませんでしたが、倍々で増えています。来年は私の口にも入るかもしれません。一株３９８円でホームセンターにて購入して増殖中です。

　すでにふきのとうは終わり、菜の花も花になり、茶の木の新芽は新緑の小さな命をあらわしています。今の時期に霜にやられると一番茶に大打撃です。私は庭にいくつかの茶の木が所有している程度なので、どうにでもなってもかまわないのですが、茶農家は大損害で茶畑では扇風機が回りだします。扇風機で霜を追い払おうって、誰が最初に考えたのでしょうね。

　花桃のほかに遅れている開花は、木苺です。まだつぼみで石垣を組んだ花壇と石の間から木苺が藪を作り、今年もたくさんの収穫が見込まれます。しかし、今年は造成の為に石垣を崩すので、食べられないでしょう。数年かけて作ったラズベリー（木苺）畑もあっという間に破壊されるのが残念です。木苺の場所も入り口付近にあって、本当はハーブ畑でイロイロ植えていたのですが、今では木苺に大方占領されています。いまではいくらかのハーブが残っている程度です。

　杉の林を造成して作った敷地で、西面が開けている以外は杉の木で覆われています。おのずと太陽の光の当たる具合が制限されて、場所によって植物が好む環境が１００坪の中でも面白いように分かれています。太陽光の熱も、エネルギーも影響しますから、広くイロイロ植えても不適合の土地には根付かないんです。面白いですね。

　（キャラ）ブキと同じ場所に菜の花を撒いたのですが、フキは大きな葉をつけるのですが、菜の花は１０数センチ程度にしかなりません。土の養分も足らないのでしょう。フキは地表下をめぐらせているので広範囲で、養分を吸収しているのが大きく違うことなのでしょうね。こうした土地に適合する力も違うのです。もっとも、菜の花は種をたくさん作って子孫を反映しようと命のつむぎ方が違うわけです。

　春になって芽吹くのは気温も関係しますが、光の長さも関係します。種の発芽といえば、トルコキキョウは静岡で大量に生産されている切花です。種の大きさが非常に小さくて種まき（播種）も大変です。このトルコキキョウは土を被せては発芽しません。光を浴びて芽が出る植物です。変わっていますね。

　いろんな植物の話をしてきました。春にはたくさんの植物が命を表現します。空気にも香りを与え、視覚的も動きがある季節になります。このときには植物自体の内部ではホルモンのめぐりも変化しますし、酵素の活性も活発になります。養分を使い、栄養を作ります。植物を始まりとした食物連鎖では当然環境全体にその恩恵を与えます。

　動物ももちろん変化によって体の仕組みも変われば、必要になってくる栄養成分も影響を与えます。このことにフォローできれば体は健康。できなければ不具合を生じさせる。それだけのこと。それだけのことを対応できればいいのです。

我が家から１分も歩けば２級河川の丸子川があります。

冬には干上がる川ですが、今年は瀬枯れすることなく流れがあります。
土手から水面を見ると透き通った流れのなかに小魚がたくさん泳いでいます。

少し前には水面には鴨や白鷺などが小魚を食べにやってきました。
おそらく最近もいるのでしょうが今日は見かけることはありませんでした。

鳥といえば、ピューロロローと風を掴んで空を滑っているタカが線空しています。
おそらく小鳥を狙っているのでしょう。他には鳩やカラス、百舌、
そうそう梅の枝にはウグイスも着ていますね。

季節の変わり目で動物も動き出しました。

あっ動物は恋の季節になりますね。


この時期はホルモンのバランスも変わり、
繁殖のメカニズムに入ってきます。

すっかり日も長くなり、長日動物は生殖に体が変化します。
生体内の仕組み、栄養の代謝が変わり、
利用される栄養素の多い少ないも成分によって違ってきます。

この時期必要な栄養素が足らないとやはり体に異常が出てきます。

体の変化に、補給する栄養素を合わせる。これは大切です。


女の子のホルモンで変化する栄養素にはフェレットの愛し方改訂版で
男の子についてはペットの栄養学、フェレットの愛し方２に記載しています。
確認して応用ください。

普段のナルヘソを少し多めにするのがこの季節乗り切るのに秘訣です

Please apply for the sample from here. We may send messages to some applicants.CHEK

1. NRHS is the supplement for ferret sold in Japan since 2000
2. Kiyoshi Nagaike, who has developed NRHS, wrote five books by 2012 and had workshops more than 60 times to spread knowledge about ferret.
3. He has started to distribute ferret in Japan since 1995 and researched ferret metabolism since 1998.
4. NRHS which is developed by his research is the special product distributed in limited shops. We prescribe this in accordance with the troubles or conditions. Therefore we have had good results even though this is not a medicine.
5. We offer “BEST IN”, which was produced in 2004, for two days as a free sample.
6. This supports ferret physical condition by supplementing nutrient shortage in dried food.
7. The retail price is JP7,350 for 100cc(60g).