辛口リリーのこれ美味しい!

【第21回 応⽤幹細胞医科学部⾨セミナー】

⽇時：2019年8⽉19⽇（⽉）17:00-18:00
場所：総合研究棟1階105号室
対象：どなたでも参加可能です
演者：伊藤 靖浩 先⽣
Research Associate Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA

講演タイトル：
Molecular investigation of corticospinal neuron axonal projection and branching at specific spinal segments
（⽇本語でのプレゼンテーションになります）

要旨：
Corticospinal neurons (CSN, and related cortico-brainstem neurons; together “CSN”) are located in layer V of the neocortex, and make synaptic connections with circuitry in the spinal cord and brainstem. CSN axons form the corticospinal tract (CST), the major motor output pathway from the cerebral cortex, essential for voluntary motor control. CSN are also clinically important. CSN degeneration in amyotrophic lateral sclerosis (ALS), along with degeneration of spinal motor neurons, causes spasticity and paralysis. In humans, damage to the CST following spinal cord injury is the principal cause of loss of voluntary motor control. Previous studies in our lab have identified combinatorial molecular controls over the specification and differentiation of CSN (1, 2).
CSN exhibit striking anatomical and functional diversity: some CSN extend axons to targets in the brainstem and cervical spinal cord (i.e. bulbar-cervical targets; referred to here as CSNBC), while others extend axons to thoraco-lumbar segments (CSNTL). CSNBC control face and arm movement, while CSNTL control trunk and hindlimb movement. We are investigating molecular mechanisms regulating CSN subpopulation-specific axonal projection and spinal segmental connectivity in mice. Furthermore, by using a novel approach our lab recently developed (3), we are investigating subcellular local transcriptomes of CSN growth cones, the tips of growing axons, during mouse CST development.

Reference:
1. Arlotta P*, Molyneaux BJ* et al., Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo, Neuron, 2005
2. Greig LC*, Woodworth MB* et al., Molecular logic of neocortical projection neuron specification, development and diversity, Nat Rev Neurosci, 2013
3. Poulopoulos A*, Murphy AJ* et al., Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex, Nature, 2019

セミナーに関する問い合わせ先：
今村　拓也　氏　
imamura★scb.med.kyushu-u.ac.jp（★を@に書き換えてください）

世話人　医学研究院　応⽤幹細胞医科学部⾨　基盤幹細胞学分野　中島欽⼀　教授

博多はつ花のボランティア修理担当が社長のブログをお借りして、発言させていただきました。

接待用高級お弁当の博多　はつ花　の商品はちょっと高級な、無農薬、無人工甘味料、無添加物を食材に使っています。配送には、冷凍車を用いております。お渡し後は、早めにお召し上がりのほど、お願い申し上げます。

ランチタイム、歓送迎会のお弁当のご予約、受付中。ご予約日は翌日以降でございます。

​